Research Paper Volume 12, Issue 4 pp 3713—3729

Identification of a lathyrane-type diterpenoid EM-E-11-4 as a novel paclitaxel resistance reversing agent with multiple mechanisms of action

Figure 2. Apoptosis as detected by Annexin V-FITC/PI binding assay (48 h) in A549/Tax cells. (A) Apoptosis induction by EM-E-11-4 (2.5, 5, and 10 μM) combined with or without 100 nM paclitaxel in A549/Tax cells. (B) The percent apoptosis in A549/Tax cells. Columns represent the means±SD values for apoptotic cells obtained from three individual experiments. * p<0.05 and ** p<0.01 vs. control (10 μM EM-E-11-4).