Research Paper Volume 12, Issue 4 pp 3713—3729

Identification of a lathyrane-type diterpenoid EM-E-11-4 as a novel paclitaxel resistance reversing agent with multiple mechanisms of action


Figure 3. Apoptosis detected by Annexin V-FITC/PI binding assay (48 h) in Hela/βIII cells. (A) Apoptosis induction by EM-E-11-4 (2.5, 5, and 10 μM) combined with or without 20 nM paclitaxel in Hela/βIII cells. (B) The percent apoptosis of Hela/βIII cells. Columns represent the means±SD values for apoptotic cells obtained from three individual experiments. * p<0.05 and ** p<0.01 vs. control (10μM EM-E-11-4).