Research Paper Volume 12, Issue 4 pp 3791—3806

Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota

Figure 7. Baicalin suppresses TMAO synthesis in repeated cerebral ischemia-reperfusion model mice. The plasma levels of (A) TMA and (B) TMAO in control, model, and baicalin-treated model group mice are shown. (C) The hepatic FMO3 expression and (D) hepatic flavin-containing monoxygeneases (FMO) activity in the control, model, and baicalin-treated model group mice are also shown. Note: *** denotes P<0.001 compared with the control mice using unpaired Student`s t-tests; ## denotes P<0.01 and ### denotes P<0.001 compared with the model mice using one-way ANOVA analysis followed by Dunnett`s post hoc test. All the values are expressed as means ± S.D. Each group had 15 mice (n=15).