Research Paper Volume 12, Issue 5 pp 4163—4177

Reduced Ca2+ spark activity contributes to detrusor overactivity of rats with partial bladder outlet obstruction

Figure 5. STOCs were increased by caffeine and decreased by ryanodine in both control and DO myocytes. (A, B) We recorded representative STOCs for control (A) and DO (B) detrusor myocytes before and after exposure to 10 μM caffeine (b) and before and after exposure to 10 μM ryanodine (c). Panels Ca and Cb provide summary data for frequencies and amplitudes of STOCs in unafflicted control and DO detrusor myocytes with regards to applications of caffeine (10 μM) and ryanodine (10 μM) (respectively). To record measures for STOCs, we clamped detrusor myocytes at -40 mV. We used one-way ANOVA for comparison between groups. VS control, *P < 0.05, and **P < 0.01; VS DO, Δ P < 0.05, and ΔΔ P < 0.01.