Transient ischemia-reperfusion induces cortical hyperactivity and AMPAR trafficking in the somatosensory cortex

Yuanyuan Li; Ran Ding; Feifei Wang; Cuiping Guo; Aili Liu; Liangpeng Wei; Shiyang Yuan; Feng Chen; Shaowei Hou; Zengguang Ma; Yan Zhang; Robert H. Cudmore; Xiaochuan Wang; Hui Shen

doi:doi:10.18632/aging.102881

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Research Paper Volume 12, Issue 5 pp 4299—4321

Transient ischemia-reperfusion induces cortical hyperactivity and AMPAR trafficking in the somatosensory cortex

Figure 7. The correlation between changes in Ca²⁺ transients and changes in AMPAR intensity after transient global ischemia-reperfusion. (A) The overall trend of the average frequency of Ca²⁺ transients and the Spine sGluA1 intensity (SEP-GluA1 signal) before and after 6 hours of ischemia-reperfusion. (B) The overall trend of the average frequency of Ca²⁺ transients and the Spine sGluA1 intensity (SEP-GluA1 signal) before and after 28 days of ischemia-reperfusion.