Priority Research Paper Volume 12, Issue 5 pp 4052—4066

Survey of senescent cell markers with age in human tissues

Figure 2. Skin. (A, B) Cells expressing p16 (A) or p21 (B) were identified by IHC staining in the epidermis of Young, Middle-aged, and Old donors. (C, D) Cells expressing p16 (C) or p21 (D) were identified by IHC staining in the dermis from Young, Middle-aged, and Old donors. Graphs represent the quantification (%) of p16-positive (A) and p21-positive (B, D) cells from 5 tissue cores from independent donors per organ and age group; data represent the means ±SD from 5 different donors. p values were determined by one-way ANOVA with Tukey adjustments for multiple comparisons where appropriate. **, p < 0.01; *, p < 0.05.