Priority Research Paper Volume 12, Issue 5 pp 4052—4066

Survey of senescent cell markers with age in human tissues

Figure 3. Kidney. (A, B) Cells expressing p16 (A) or p21 (B) were identified by IHC staining in the renal cortex of kidney of Young, Middle-aged, and Old donors. (C) Decreased magnification images showing p16-positive cells in the Bowman capsule of Old donors. Graphs represent the quantification (%) of p16-positive (A) and p21-positive (B) cells from 5 tissue cores from independent donors per organ and age group; data represent the means ±SD from 5 different donors. p values were determined by one-way ANOVA with Tukey adjustments for multiple comparisons where appropriate. **, p < 0.01; *, p < 0.05.