Research Paper Volume 12, Issue 6 pp 4866—4878

MiR-519d targets HER3 and can be used as a potential serum biomarker for non-small cell lung cancer

Figure 5. MiR-519d inhibits A549 cell migration and invasion and induces cell apoptosis. (A) Transfection of miR-519d mimic suppressed the expression of HER3 and inhibited A549 cell migration and invasion. (B) Transfection of miR-519d inhibitor increased the expression of HER3 and enhanced A549 cell migration and invasion. (C) Upregulation of miR-519d significantly enhanced A549 cell apoptosis, but suppression of miR-519d significantly reduced A549 cell apoptosis. **p<0.01 vs. control, ***p<0.001 vs. control.