Research Paper Volume 12, Issue 5 pp 4573—4591

APEX1 is a novel diagnostic and prognostic biomarker for hepatocellular carcinoma

Figure 5. APEX1 expression is significantly higher in the HCC patients with low AFP expression and is a better diagnostic biomarker. (A, B) APEX1 and AFP mRNA expression in the liver cirrhosis (n=40) and HCC patients with low AFP expression (n=134) from the GSE25097 dataset is shown. The 134 HCC patients with low AFP expression were selected based on the median expression of AFP in 268 HCC patients from the GSE25097 dataset. (C) ROC curve analysis shows the diagnostic values of APEX1 and AFP in 134 HCC patients with low AFP expression from the GSE25097 dataset. (D, E) APEX1 and AFP mRNA expression in the liver cirrhosis (n=168) and HCC patients with low AFP expression (n=114) from the GSE63898 dataset is shown. The 114 HCC patients with low AFP expression were selected based on the median expression of AFP in 228 HCC patients in the GSE63898 dataset. (F) ROC curve analysis shows the diagnostic value of APEX1 and AFP in 114 HCC patients with low AFP expression from the GSE63898 dataset.