Research Paper Volume 12, Issue 6 pp 4953—4969

RNA sequencing analysis of monocrotaline-induced PAH reveals dysregulated chemokine and neuroactive ligand receptor pathways

Figure 6. The change of cytokine-cytokine receptor interaction in response to MCT treatment. (A) KEGG pathway map showing change of cytokine-cytokine receptor interaction, DEGs with relatively increased and reduced expression were shown in red and blue, respectively, while green represented background genes. KEGG pathway only at week 4 was showed. (B) Heatmap and hierarchical clustering analysis of DEGs that were annotated in the chemokines and receptors in cytokine-cytokine receptor interaction, (C) Heatmap and hierarchical clustering of DEGs that were annotated in the TNF families and receptors in cytokine-cytokine receptor interaction.