Research Paper Volume 12, Issue 6 pp 5071—5090

Comprehensive analysis of circular RNA profiles in skeletal muscles of aging mice and after aerobic exercise intervention

Figure 3. Overview of altered circRNA in different sequencing group. (A) Volcano plots showing differential expression of circRNAs of Aging group compared with Young group. Differentially expressed circRNAs with fold change > 2 and p < 0.05 were marked in orange and green dots representing up and down regulation separately. (B) Volcano plots showing differential expression of circRNAs of Aging plus Exercising compared to Aging group. Differentially expressed circRNAs with fold change > 2 and p < 0.05 were marked in orange and green dots representing up and down regulation separately. (C) The top 10 upregulated and 10 downregulated circRNA based on the log2 fold change of Aging group compared with Young group. (D) The top 10 upregulated and 10 downregulated circRNA based on the log2 fold change of Aging plus Exercising group compared to Aging group.