Research Paper Volume 12, Issue 6 pp 5183—5194

LncRNA AGAP2-AS1 augments cell viability and mobility, and confers gemcitabine resistance by inhibiting miR-497 in colorectal cancer

Figure 6. AGAP2-AS1 exerted carcinogenic function in CRC by regulating the miR-497/FGFR1 axis. (A) Increased cell viability induced by AGAP2-AS1 overexpression was abolished after miR-497 overexpression or FGFR1 knockdown by CCK-8 assay. (B) Increased gemcitabine resistance in CRC cells after pWPXL-AGAP2-AS1 transfection was abolished by miR-497 overexpression or FGFR1 knockdown. (C) AGAP2-AS1 overexpression suppressed gemcitabine-induced apoptosis and this effect was partially inhibited by miR-497 overexpression or FGFR1 knockdown. (D) miR-497 overexpression or FGFR1 knockdown blocked CRC cell migration induced by AGAP2-AS1. *P < 0.05; **P < 0.01.