Research Paper Volume 12, Issue 6 pp 5439—5468

Identification of hub genes in hepatocellular carcinoma using integrated bioinformatic analysis

Figure 3. Identification of 12 upregulated hub genes among HCC datasets. (A) Among the 176 upregulated genes, 57 genes with higher protein levels in HCC tissues based on GSE124535 datasets were obtained. (B) We identified 12 upregulated hub genes by considering genes that were negatively associated with overall survival (OS) and disease-free survival (DFS) in HCC patients and genes that were hypomethylated. (CF) Analysis of the association between CDK1 (C), FEN1 (D), KPNA2 (E), and LRRC1 (F) expression and OS/DFS among HCC patients in the TCGA cohort. (GJ) Analysis of the association between CDK1 (C), FEN1 (D), KPNA2 (E), and LRRC1 (F) expression and cancer stage/tumor grade among HCC patients in the TCGA cohort. p-values are shown in Supplementary Table 3.