Research Paper Volume 12, Issue 6 pp 5439—5468

Identification of hub genes in hepatocellular carcinoma using integrated bioinformatic analysis

Figure 9. Methylation and gene copy number analyses of upregulated hub genes. (AD) Methylation levels of CDK1 (A), FEN1 (B), KPNA2 (C), and LRRC1 (D) in primary hepatocellular carcinoma (HCC) tumors and normal tissues from the TCGA cohort. (EH) Correlation analysis of methylation levels of CDK1 (E), FEN1 (F), KPNA2 (G), and LRRC1 (H) and their mRNA expression in HCC based on the TCGA cohort. (IL) Correlation analysis of gene copy numbers of CDK1 (I), FEN1 (J), KPNA2 (K), and LRRC1 (L) and their mRNA expression in HCC based on the TCGA cohort. (MO) Survival analysis of the correlation between methylation levels of KPNA2 (M), LRRC1 (N), and MCM3 (O) and overall survival (OS) in HCC patients from the TCGA cohort. (PQ) Analysis of the association between KPNA2 (P) and MCM3 (Q) methylation and pathologic T stage in HCC patients of the TCGA cohort.