Research Paper Volume 13, Issue 8 pp 12179—12193

circRNA_141539 can serve as an oncogenic factor in esophageal squamous cell carcinoma by sponging miR-4469 and activating CDK3 gene

Rescue experiment, miR-4469 reversed the effects of circRNA

Figure 8. Rescue experiment, miR-4469 reversed the effects of circRNA_141539 on CDK3 expression and cell proliferation. (A) qRT-PCR assay showed the effects of circRNA_141539/miR-4469 axis on CDK3 mRNA expression. *P < 0.05, **P < 0.01 versus corresponding NC group. (B) MTT assay showed the effects of circRNA_141539/miR-4469 axis on cell proliferation. *P < 0.05, **P < 0.01 versus corresponding NC group.