Research Paper Volume 12, Issue 10 pp 8913—8922

HIX003209 promotes vascular smooth muscle cell migration and proliferation through modulating miR-6089

Figure 2. HIX003209 was upregulated in VSMCs induced by inflammatory mediators. (A) TNF-α promoted VSMC proliferation using CCK-8 method when compare to control group. (B) HIX003209 expression was upregulated in VSMCs induced by TNF-α when compare to control group. (C) ox-LDL induced VSMC growth using CCK-8 kit when compare to control group. (D) The expression of HIX003209 was determined with qRT-PCR analysis. (E) PDGF-BB enhanced VSMCs proliferation using CCK-8 kit when compare to control group. (F) The expression of HIX003209 was determined with qRT-PCR analysis. *p<0.05, **p<0.01 and ***p<0.001. The data were shown as HIX003209/GADPH.