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Research Paper Volume 12, Issue 9 pp 7945—7962

Osthole alleviates neuropathic pain in mice by inhibiting the P2Y1-receptor-dependent JNK signaling pathway

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Figure 3. Osthole cut down P2Y1R up-regulation and p-JNK activation on a concentration-dependent manner. (A–C) Osthole decreased P2Y1R of CCI mice on a concentration dependent manner. ###p<0.01, compared with sham group; **p<0.05, ***p<0.01, compared with CCI group, ANOVA followed by Bonferroni post-hoc test, n=6 mice/group. (D, E) Osthole reduced p-JNK expression after CCI in the spinal cord on POD 14. ###p<0.01, compared with sham group; **p<0.05, ***p<0.01, compared with CCI group, ANOVA followed by Bonferroni post-hoc test, n=6 mice/group. (F) Osthole reduced inflammatory factors after CCI in the spinal cord on POD 14. ###p<0.01, compared with sham group; ***p<0.01, compared with CCI group, ANOVA followed by Bonferroni post-hoc test, n=6 mice/group. All data are means ± S.D.