Figure 5. Abnormal DNA copy numbers and DNA methylation are linked in SKCM. (A, F) Abnormalities in DNA copy numbers or DNA methylation were determined based on a cutoff fold difference >0.2 compared to average values in non-tumor tissues. DNA copy-number gains (CNVgain) and losses (CNVloss) and DNA hypermethylation (METhyper) and hypomethylation (METhypo) are shown for each sample. (B–E) Plots show the pairwise frequencies of CNVgain, CNVloss, METhyper, and METhypo genes in individual samples.