Research Paper Volume 12, Issue 9 pp 8289—8300

Pluronic P123 modified nano micelles loaded with doxorubicin enhanced tumor-suppressing effect on drug-resistant breast cancer cells

Figure 4. P123-PEG2000-DSPE (Dox) inhibited cell growth in MCF-7 and MCF-7R cells. (A) Cell viability of MCF-7 and MCF-7R cells treated with different doses of PEG2000-DSPE (unloaded nano micelles) at 24 h by MTT assay. (B) Cell viability of MCF-7 and MCF-7R cells treated with different doses of P123-PEG2000-DSPE at 24 h by MTT assay. (C) Cell viability of MCF-7 cells treated with PBS (control), Dox, PEG2000-DSPE (Dox) or P123-PEG2000-DSPE (Dox) by MTT assay. (D) Cell viability of MCF-7R cells treated with PBS (control), Dox, PEG2000-DSPE (Dox) or P123-PEG2000-DSPE (Dox) by MTT assay.