Research Paper Volume 12, Issue 9 pp 8397—8412

EFEMP2 indicates assembly of M0 macrophage and more malignant phenotypes of glioma

Figure 1. WHO grade, IDH1 mutation and transcriptomic subtype preferences of EFEMP2 expression. (A) The correlation of EFEMP2 expression level with WHO grade. EFEMP2 expression levels in glioma of WHO grade II-IV in CGGA RNA-seq, TCGA RNA-seq, GSE16011 and REMBRANDT databases. ***p < 0.0001. (B) EFEMP2 expression in glioma specimens determined by IHC analysis. Scale bar, 60 μm. (C) The relationship between EFEMP2 transcription level and IDH1 mutation in CGGA and TCGA mRNA array datasets. ***p < 0.0001. (D) The relationship between EFEMP2 transcription level and transcriptomic subtype classification in CGGA and TCGA mRNA array datasets. (E) Correlation of EFEMP2 expression and IDH1 mutation in each transcriptomic subtype in CGGA and TCGA mRNA sequencing data, and GSE16011 dataset.