Research Paper Volume 12, Issue 9 pp 8473—8483

Shoutai pills improve the quality of oocytes exposed to the chemotherapeutic drug Hydroxyurea

Figure 1. Effects of STP on the follicle development in HU-exposed ovaries. (A) Histology of ovarian sections in control, HU-exposed and STP-supplemented ovaries. Ovarian sections of 4 μm thickness were prepared and stained with H&E. Black arrows show the growing follicles at different developmental stages; green arrows indicate the developmentally arrested follicles with degenerating oocytes. CL, corpus luteum. Scale bars, 250 μm and 50 μm. (B) Quantification analysis of primordial follicles in control, HU-exposed and STP-supplemented ovaries. (C) Quantification analysis of degenerated follicles in control, HU-exposed and STP-supplemented ovaries. Data of (B, C) were presented as mean percentage (mean ± SEM) of at least three independent experiments. *P < 0.05, **P < 0.01.