Research Paper Volume 12, Issue 9 pp 8549—8564

Exosomal miRNA-34 from cancer-associated fibroblasts inhibits growth and invasion of gastric cancer cells in vitro and in vivo

Figure 9. Targeting mRNAs of miRNA-34 are determined in vitro and in vivo. (A) Heat map of expressions of targeting mRNAs of miRNA-34 in GC cell lines AGS and AZ521, as determined by qRT-PCR. (B) Heat map of expressions of targeting mRNAs of miRNA-34 in GC cells of tumor tissue, as determined by qRT-PCR. Values are means ± SD. (Abbreviation: AR: androgen receptor; CCL22: C-C motif chemokine 22; CCND1: cyclin D1; CCNE2: cyclin E2; CDK4: cyclin-dependent kinase 4; CDK6: cyclin-dependent kinase 6; c-Met: tyrosine-protein kinase Met; E2F3: E2F transcription factor 3; E2F5: E2F transcription factor 5; HMGA2: high-mobility group AT-hook 2; LMTK3: lemur tyrosine kinase 3; MTA2: metastasis associated 1 family member 2; N-Myc: N-myc proto-oncogene protein; PAR2: proteinase activated receptor 2; SFRS2: serine/arginine-rich splicing factor 2; SIRT1: silent information regulator 1).