Research Paper Volume 12, Issue 10 pp 9041—9065

Sigma-1 receptor is involved in diminished ovarian reserve possibly by influencing endoplasmic reticulum stress-mediated granulosa cells apoptosis

Figure 6. The decrease of apoptosis rates in thapsigargin(TG)-induced ERS KGN cells treated with PRE-084/DHEA was accompanied by the decrease of ERS-related and apoptosis-related gene expression. (A) Apoptosis index in KGN cells treated with different drugs. (B) Flow cytometry sorting of sigma-1 receptor protein in KGN cells treated with different drugs.