Research Paper Volume 12, Issue 10 pp 9066—9084

Overexpression of miR-142-5p inhibits the progression of nonalcoholic steatohepatitis by targeting TSLP and inhibiting JAK-STAT signaling pathway

Figure 6. The effect of molecular interference sequences on the expression of miR-142-5p and TSLP. (A) Relative expression level of miR-142-5p in different groups. (B) The relative mRNA expression of TSLP. (C) The protein expression level of TSLP. WT group: wild-type mice fed a chow diet; blank group: Ldlr−/− mice fed an HFD treated with phosphate buffer saline; NC group: Ldlr−/− mice fed an HFD treated with sh-control; sh-TSLP group: Ldlr−/− mice fed an HFD treated with sh-TSLP; sh-TSLP-C group: Ldlr−/− mice fed an HFD treated with sh-TSLP and colivelin (JAK-STAT signaling pathway activator). Each group contained 6 mice. *P < 0.05, **P < 0.01, compared with WT group; #P < 0.05, compared with NC group. All data were means ± SD.