Research Paper Volume 12, Issue 10 pp 9151—9172

Downregulation of miRNA-146a-5p promotes malignant transformation of mesenchymal stromal/stem cells by glioma stem-like cells

Figure 7. Overexpression of miR-146a-5p partially reversed the malignant phenotype of tMSCs. (A) Relative expression of miR-146a-5p after lentiviral vector transfection; (B) Cell proliferation activity of miR-146a-5p-overexpressing, negative control (NC) and blank control (BC) tMSC1 cells; (C) Colony formation assays of BC, NC and miR-146a-5p-overexpressing tMSC1 and tMSC2 cells; (D) Invasion assays of NC and miR-146a-5p-overexpressing tMSC1 and tMSC2 cells; (E) Tumorigenicity of NC and miR-146a-5p-overexpressing tMSC1 cells. * P<0.05, ** P<0.01, *** P<0.001.