Research Paper Volume 12, Issue 10 pp 9205—9223

Identification of potential novel differentially-expressed genes and their role in invasion and migration in renal cell carcinoma

Figure 4. Transcriptional expression of TIMP1 significantly correlated with advanced clinicopathological parameters and poor survival outcomes in ccRCC patients. (A) Oncomine analysis of cancer vs. normal tissue of TIMP1. Heat maps of TIMP1 gene expression in clinical hepatocellular carcinoma samples vs. normal tissues. 1. Clear Cell Renal Cell Carcinoma vs. Normal, Higgins, Am J Pathol, 2003 [49]. 2. Clear Cell Renal Cell Carcinoma vs. Normal, Yusenko, BMC Cancer, 2009 [50]. 3. Clear Cell Renal Cell Carcinoma vs. Normal, Jones J, Clin Cancer Res, 2005 [51]. 4. Clear Cell Renal Cell Carcinoma vs. Normal, Gumz ML, Clin Cancer Res, 2007 [52]. (B) Transcriptional expression of TIMP1 was significantly correlated with AJCC stage, patients who were in a more advanced stage tended to express higher mRNA expression of TIMP1. (C) Transcriptional expression of TIMP1 was significantly correlated with ISUP grade. Patients in a more advanced grade tended to exhibit elevated TIMP1mRNA expression. Abbreviations: ccRCC: clear cell renal cell carcinoma.