Research Paper Volume 12, Issue 10 pp 9224—9239

Apelin enhances IL-1β expression in human synovial fibroblasts by inhibiting miR-144-3p through the PI3K and ERK pathways

Figure 7. Schematic diagram summarizes the mechanism whereby APLN promotes IL-1β production in OASFs. APLN induces inflammatory IL-1β production in OASFs by downregulating miR-144-3p through the PI3K and ERK signaling pathways.