Research Paper Volume 12, Issue 9 pp 8710—8727

Soy isoflavones improve the oxidative stress induced hypothalamic inflammation and apoptosis in high fat diet-induced obese male mice through PGC1-alpha pathway

Figure 6. Soy isoflavones increase PGC1-alpha transcription in hypothalamus of DIO male mice. (A) Quantification shows the mRNA levels of PGC1-alpha in hypothalamus of DIO mice fed with basal diets and the addition with different doses of soy isoflavones; (B) Quantification shows the mRNA levels of SOD2 in hypothalamus of DIO mice fed with basal diets and the addition with different doses of soy isoflavones; (C) Quantification shows the mRNA levels of GPx in hypothalamus of DIO mice fed with basal diets and the addition with different doses of soy isoflavones; (DG) Western blots and quantification show the protein levels of PGC1-alpha, SOD2 and GPx in hypothalamus of DIO mice fed with basal diets and the addition with different doses of soy isoflavones. * p < 0.05, ** p < 0.01, ***p < 0.001.