Research Paper Volume 12, Issue 10 pp 9292—9310

PIWI-interacting RNAs piR-13643 and piR-21238 are promising diagnostic biomarkers of papillary thyroid carcinoma

Figure 7. Validation of target genes of piRNA-13643 and piRNA-21238. (A) Result of hierarchical clustering for differential genes in thyroid cancer and noncancerous tissue was calculated by TCGA database. (B) Result of volcano for differential genes in thyroid cancer and noncancerous tissue was calculated by TCGA database. (C) Result of hierarchical clustering for differential genes in thyroid cancer with or without metastasis tissue was calculated by TCGA database. (D) Result of volcano for differential genes in thyroid cancer with or without metastasis tissue was calculated by TCGA database. (E) piRNA-13643 target genes prediction using differential genes in thyroid cancer and noncancerous tissue in TCGA database. (F) piRNA-21238 target genes prediction using differential genes in thyroid cancer and noncancerous tissue in TCGA database. (G) piRNA-13643 target prediction using differential genes in thyroid cancer with or without metastasis tissue in TCGA database. (H) piRNA-21238 target prediction using differential genes in thyroid cancer with or without metastasis tissue in TCGA database. (I) Gene Ontology (GO) analysis of piRNA-13643 associated with biological process, molecular function and cellular component. (J) Top twenty signal pathways of piRNA-13643 by KEGG.