Research Paper Volume 12, Issue 10 pp 9365—9379

Association of cerebrospinal fluid neurogranin levels with cognition and neurodegeneration in Alzheimer’s disease

Figure 2. Receiver operating characteristic curves for the diagnostic utility of CSF biomarkers. (A) Receiver operating characteristic curves for the diagnostic utility of CSF biomarkers in differentiating AD from controls by clinical diagnosis (AD versus CN). The diagnostic accuracy (area under the receiver operating characteristic curve [AUC]) of CSF Ng in differentiating patients with AD from controls was comparable to that of the core CSF biomarkers. (B) Receiver operating characteristic curves for the diagnostic utility of CSF Ng in differentiating AD from controls by biological status (A+T+ versus A-T-). Abbreviations: CSF: cerebrospinal fluid; Ng, neurogranin; Aβ, amyloid-β; p-tau, phosphorylated tau; t-tau, total tau.