Research Paper Volume 12, Issue 10 pp 9405—9426

Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis

Figure 3. Sal alleviated pyroptosis in PD mice. (A) Sal inhibited MPTP-induced the increase of IL-1β and IL-18 in SN and striatum of PD mice by enzyme-linked immunosorbent assay (ELISA) kits (n = 6). (B) Sal inhibited the expression of cleaved GSDMD, IL-1β and IL-18 in SN and striatum of PD mice by Western blotting. (n = 3). All data are represented as mean ± SD. # P < 0.05, ## P < 0.01 vs. control group, *P < 0.05, **P < 0.01 vs MPTP group.