Research Paper Volume 12, Issue 10 pp 9405—9426

Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis

Figure 5. Sal inhibited pyroptosis via NLRP3/ASC/Caspase-1 signaling pathways in PD mice. (A) Sal inhibited TXNIP, NLRP3, ASC and cleaved Caspase-1 in SN and striatum of PD mice by western blotting (n = 3). (B) Sal inhibited TXNIP in SN and striatum by immunohistochemical staining. Original magnification: x200. All data are represented as mean ± SD. # P < 0.05, ## P < 0.01 vs. control group, *P < 0.05, **P < 0.01 vs MPTP group.