Research Paper Volume 12, Issue 10 pp 9549—9584

MiR-1908/EXO1 and MiR-203a/FOS, regulated by scd1, are associated with fracture risk and bone health in postmenopausal diabetic women

Figure 4. The establishment and validation of the risk prediction model of diabetic fracture. (A) Developed diabetic fracture nomogram. Note: The diabetic fracture nomogram was developed in the cohort, with hsa-miR-550a-5p, hsa-miR-382-3p, hsa-miR-369-3p, hsa-miR-376c-3p, hsa-miR-1908, hsa-miR-203a and hsa-miR-942 incorporated. (B) Predictive factors of fractures in patients with DM2. (C) Differential miRNA expression levels between with (DMFX) and without (DM) fragility fractures in the postmenopausal women with type 2 diabetes. To enable intuitive interpretation of upregulation and down-regulation, Cq values are inverted along the y axis. (D) Decision curve analysis for the diabetic fracture nomogram. (E) Enrichment analysis of hsa-miR-550a-5p, hsa-miR-382-3p, hsa-miR-369-3p, hsa-miR-376c-3p, hsa-miR-1908, hsa-miR-203a and hsa-miR-942 using mirPath v.3.