Research Paper Volume 12, Issue 10 pp 9745—9760

Loss of macroH2A1 decreases mitochondrial metabolism and reduces the aggressiveness of uveal melanoma cells

Figure 2. Proliferation and migration of UM 92.1 cells KD for macroH2A1. (A) Real time cell proliferation monitored by xCELLigence system. Cell index values were normalized at the time zero in order to obtain a normalized cell index. Each line is expressing the average of four different experiments. (B) Cell proliferation assay. Values are presented as percentage of the open wound following 4, 8, 24 and 48 hours (wound at time 0 was assumed as 100% and used as control). Values are expressed as the mean ± SEM of three different experiments. (p < 0.0001 vs control). (C) The migration assay. Values are presented as number of migrating cells following 1, 4, 6 and 8 hours (wound at time 0 was assumed without migrating cells and used as control). Values are expressed as the mean ± SEM of three independent experiments. (p < 0.0001 vs control).