Research Paper Volume 12, Issue 10 pp 9761—9780

Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone

Figure 4. ANCOVA shows that GH-deficiency alters body composition parameters. Body composition parameters were measured by DXA. Body composition parameters are plotted on the y-axis and body weights are plotted on the x-axis (AH). Relationship between body weight and BMD in female (A) and male (B) WT and GHRH-/- mice. Relationship between body weight and BMC in female (C) and male (D) WT and GHRH-/- mice. Relationship between body weight and lean mass in female (E) and male (F) WT and GHRH-/- mice. Relationship between body weight and fat mass in female (G) and male (H) WT and GHRH-/- mice. Female WT n=38, GHRH-/- n=31, male WT n=16, GHRH-/- n=14. The WT and GHRH-/- groups were statistically analyzed with ANCOVA method, which was used to calculate p values, shown on each panel.