Research Paper Volume 12, Issue 10 pp 9793—9806

Circular RNA hsa_circ_0003141 promotes tumorigenesis of hepatocellular carcinoma via a miR-1827/UBAP2 axis

Figure 7. Hsa_circ_0003141 functions as oncogene in Hun-7 cells by sponging miR-1827, and thus increasing UBAP2 expression. (A) Western analysis of UBAP2 and cleaved caspase 3 in Huh-7 cells transfected with hsa_circ_0003141-shRNA1 with and without miR-1827 inhibitor. (B, C) The relative expression of UBAP2 and cleaved caspase 3 in Huh-7 cells normalized to β-actin. **P < 0.01, compared with the shRNA-NC group. ##P < 0.01, compared with the circRNA_shRNA1 group.