Research Paper Volume 12, Issue 10 pp 9807—9824

Identification and validation of hub microRNAs dysregulated in esophageal squamous cell carcinoma

Figure 6. Expression analysis and prognostic value of miR-196-5p and miR-1-3p in ESCC. (A) Analysis of miR-196a-5p expression by qPCR in ESCC and normal esophageal epithelial (Het1A) cells. (B) Expression of miR-196a-5p in ESCC and normal esophagus samples from TCGA. (C) Expression of miR-196a-5p in ESCC and paired normal tissue samples (n = 32) collected at our institution. (D) Expression of miR-1-3p in ESCC and Het1A cells. (E) Expression of miR-1-3p in ESCC and normal esophagus samples from TCGA. (F) Expression of miR-1-3p in ESCC samples and paired normal tissue samples (n = 32) collected at our institution. (G and H) Kaplan-Meier survival analysis based on miR-196a-5p and miR-1-3p expression in esophageal carcinoma samples from TCGA. *P < 0.05, **P < 0.01. ***P < 0.001, and ****P < 0.0001.