Research Paper Volume 12, Issue 13 pp 12812—12840

PHLPP2 is regulated by competing endogenous RNA network in pathogenesis of colon cancer

Figure 11. Overexpression of PHLPP2, LINC00402, LINC00461, and SFTA1P or the inhibition of miR-141 and miR-424 inhibits the growth of formed tumor and reduces the tumor volume. (A) Representative images, tumor volume, and tumor weight of formed tumors in nude mice harboring NC or PHLPP2. (B) Representative images, tumor volume, and tumor weight of formed tumors in nude mice harboring antagomir NC or miR-141 antagomir. (C) Representative images, tumor volume and tumor weight of formed tumors in nude mice harboring antagomir NC or miR-424 antagomir. (D) Representative images, tumor volume, and tumor weight of formed tumors in nude mice harboring NC-pcDNA or pcDNA-LINC00402. (E) Representative images, tumor volume, and tumor weight of formed tumors in nude mice harboring NC-pcDNA or pcDNA-LINC00461. (F) Representative images, tumor volume and tumor weight of formed tumors in nude mice harboring NC-pcDNA or pcDNA-SFTA1P. * p < 0.05 vs. the NC-pcDNA group. Measurement data in this Figure were expressed as the mean ± standard deviation, with comparisons between two groups conducted by t-test (n = 5); the experiment was repeated three times independently.