Research Paper Volume 12, Issue 19 pp 18970—18981

LINC00963 facilitates acute myeloid leukemia development by modulating miR-608/MMP-15

Figure 6. MMP-15 was a target of miR-608. (A) An online database (TargetScan) predicted that MMP-15 was a potential target of miR-608. (B) Luciferase reporter assays verified that elevated expression of miR-608 decreased the luciferase value in the MMP-15-wt group but did not change the luciferase value in the MMP-15-mut group. (C) Overexpression of miR-608 suppressed MMP-15 levels in THP-1 cells. (D) Ectopic expression of LINC00963 upregulated MMP-15 levels in THP-1 cells. *p<0.05. GAPDH was used as the internal control.