Research Paper Volume 12, Issue 11 pp 10663—10675

Association between immune-related adverse events and efficacy of PD-1 inhibitors in Chinese patients with advanced melanoma

Figure 3. Subgroup analysis to evaluate the association between the number or grade of the irAEs and the prognosis. Shown are the PFS and OS curves for patients with irAEs of different (A) numbers and (B) grades. Patients with three or more irAEs showed longer PFS and OS when compared with those with one to two irAEs or none (P < 0.05). Patients with grade 1 to 2 irAEs showed longer PFS and OS when compared with those with no irAEs (P < 0.01).