Research Paper Volume 12, Issue 13 pp 13005—13022

MicroRNA-124 inhibits macrophage cell apoptosis via targeting p38/MAPK signaling pathway in atherosclerosis development

Figure 5. MiR-124 agomir inhibited CD68, pro-inflammatory cytokines and promoted anti-inflammatory cytokines in the thoracic aorta of atherosclerosis model mice. (A) Hematoxylin and eosin staining of thoracic aorta specimens from atherosclerosis model mice treated with agomir control or agomir-124. Bar = 200 μm. (B) Immunohistochemistry analysis of the protein levels of CD68. Bar = 100 μm. (C) Immunohistochemistry analysis of the pro-inflammatory cytokines and anti-inflammatory cytokines in the thoracic aorta of atherosclerosis model mice treated with agomir control or agomir-124. Bar = 100 μm. *, P <0.01, **, P <0.01, ***, P <0.001 compared with control group.