Research Paper Volume 12, Issue 13 pp 13005—13022

MicroRNA-124 inhibits macrophage cell apoptosis via targeting p38/MAPK signaling pathway in atherosclerosis development

Figure 7. MiR-124 inhibited the apoptosis and p38 promoted the apoptosis of RAW264.7 cells. (A) Annexin V/PI staining was performed on RAW264.7 cells transfected with the miR-124 mimics, inhibitor or negative control, then treated with ox-LDL for 48 h. After that, the fluorescence was measured using flow cytometry. (B) Annexin V/PI staining was performed on RAW264.7 cells transfected with p38 siRNA, p38 pcDNA 3.1. *, # P < 0.05.