Research Paper Volume 12, Issue 13 pp 13115—13127

ROR2 knockdown suppresses breast cancer growth through PI3K/ATK signaling

Figure 4. ROR2 induces PI3K/AKT signaling in BC cells. (A) qRT-PCR of PI3K, AKT, PDK1, p21, and cyclin D1 in MDA-MB-231 and MCF-7 cells after siROR2 and pLenti-ROR2 transfection. (B, C) Western blotting of PI3K, AKT, pAKT, PDK1, p21, and cyclin D1 in MDA-MB-231 and MCF-7 cells after siROR2 and pLenti-ROR2 transfection. Results are shown as means ± SD; n=3; *p<0.05, **p<0.01.