Research Paper Volume 12, Issue 13 pp 13220—13233

Cancer-associated fibroblasts-derived gamma-glutamyltransferase 5 promotes tumor growth and drug resistance in lung adenocarcinoma

Figure 4. Increased GGT5 in CAFs promotes the drug resistance of LUAD cells. (A) Apoptosis cells of A549 and LAC1 cells treated with Paclitaxel (5 μM) or Cisplatin (200 μM) were analyzed under normal culture medium (Normal-M) or conditioned media from NFs transfected with vector (Vector-M) or GGT5 (GGT5-M). (B) The IC50 values of Paclitaxel and Cisplatin for A549 and LAC1 cells under Normal-M (DMEM + 10%FBS) or conditioned media from CAFs (Scramble-M or siGGT5-M). In panels A and B, data represent mean ± SEM. ns, no significant difference. **, P < 0.01; ***, P < 0.001.