Research Paper Volume 12, Issue 13 pp 13365—13387

TCF7L2 rs290487 C allele aberrantly enhances hepatic gluconeogenesis through allele-specific changes in transcription and chromatin binding

Figure 1. The expression of liver TCF7L2 transcripts correlated with rs290487 variant and the diabetic status of cirrhotic patients. (A) QRT-PCR analysis shows that the levels of total TCF7L2 mRNA and the liver-specific alternately spliced TCF7L2 transcripts containing exons 11-12-13 and exons 6-12bp are significantly higher in patients with the rs290487 C/C genotype compared to those with the rs290487 T/T genotype. (B) QRT-PCR analysis shows that levels of total TCF7L2 mRNA in the liver and liver-specific alternately spliced TCF7L2 transcripts containing exons 11-12-13, exons 6-12bp, and exons 11-13-14 were significantly higher in HD patients compared to the non-HD patients. (C) Correlation analysis shows that HOMA-IR value is positively associated with the levels of total TCF7L2 mRNA in the liver and the levels of liver-specific TCF7L2 transcripts. Note: *P< 0.05; ** P< 0.01.