Research Paper Volume 12, Issue 13 pp 13365—13387

TCF7L2 rs290487 C allele aberrantly enhances hepatic gluconeogenesis through allele-specific changes in transcription and chromatin binding

Figure 8. The proposed mechanism underlying changes in hepatic glucose metabolism in the TCF7L2 rs290487 C variant. The TCF7L2 rs290487 C variant shows changes in the levels of alternately spliced TCF7L2 transcripts, decreased TCF7L2 protein, and altered transcription factor-DNA binding affinity and TCF7L2 binding sites, which eventually promotes gluconeogenesis and decreases glycolysis in the rs290487 C variant when compared with the rs290487 T variant.