Research Paper Volume 12, Issue 13 pp 13701—13715

Exome sequencing identifies somatic mutations in novel driver genes in non-small cell lung cancer

Figure 4. Downstream gene expression in samples and cell lines with KEAP1/NFE2L2 mutations. (A) There were significant differences in UGT1A1, GSTA and NQO1 expression between tumors with and without KEAP1 or NFE2L2 mutations. (B) There were significant differences in GCLC, GCLM, TXN, TXNRD, NQO1, G6PD, and GSR expression between cell lines with and without KEAP1 or NFE2L2 mutations. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.