Figure 4. Downstream gene expression in samples and cell lines with KEAP1/NFE2L2 mutations. (A) There were significant differences in UGT1A1, GSTA and NQO1 expression between tumors with and without KEAP1 or NFE2L2 mutations. (B) There were significant differences in GCLC, GCLM, TXN, TXNRD, NQO1, G6PD, and GSR expression between cell lines with and without KEAP1 or NFE2L2 mutations. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.