Research Paper Advance Articles

Expression and prognosis analysis of DNMT family in acute myeloid leukemia

Figure 6. Molecular signatures associated with DNMT3A in AML. (A) Volcano plot of differentially expressed genes between AML patients with low and high DNMT3A expression (FDR<0.05, P<0.05, and |log2 FC|>1.5). (B) Gene Ontology analysis of DEGs conducted using online website of STRING (http://string-db.org). (C) Expression heatmap of differentially expressed microRNAs between AML patients with low and high DNMT3A expression (FDR<0.05 and P<0.05). (D) Venn results of microRNAs which could target DNMT3A predicted by DIANA (http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=microT_CDS/index), miRDB (http://mirdb.org/miRDB/), TargetScan (http://www.targetscan.org/vert_72/), miRDB (http://mirdb.org/), and starBase (http://www.sysu.edu.cn/403.html).