Research Paper Volume 12, Issue 13 pp 13762—13790

Aging affects sex- and organ-specific trace element profiles in mice

Figure 2. TE profile analysis in the liver of mice. Liver tissue of adult (24 weeks) and old (109-114 weeks) male and female C57BL/6Jrj mice (n = 4-5) receiving chow diet were analyzed for their concentrations of Mn (A), Zn (B), Se (C), Fe (E), and Cu (F) using ICP-MS/MS. Furthermore, Se-sensitive GPX activity was assessed by NADPH-consuming assay (D). Statistical testing based on Two-Way ANOVA and post hoc analysis using Bonferroni’s test revealed no significant differences for age and sex.