Research Paper Volume 12, Issue 15 pp 15374—15391

Stearoyl-CoA desaturase 1 (SCD1) facilitates the growth and anti-ferroptosis of gastric cancer cells and predicts poor prognosis of gastric cancer

class="figure-viewer-img"

Figure 5. Oncogenic activity of SCD1 in xenograft mice model. (A) Representative mice and tumor nodules in each group were shown. (B) Tumor volumes were analyzed (n = 5), results were shown as mean ± SEM (Student t test). (C) Tumor weights were calculated (n = 5), results were shown as mean ± SEM (Student t test). (D) Immunofluorescent staining of the indicated markers were performed. Scale bar, 50 μm. (E) the SCD1, Twist1 and Ki67 positive cells in the tumors were analyzed by using image J software, and results were shown as mean ± SEM (Student t test). (F) Representative mice and tumor nodules in each group were shown. (G) tumor volumes were analyzed (n = 3), results were shown as mean ± SEM (the analysis of variance test). (H) Tumor weights were calculated (n = 3), and results were shown as mean ± SEM (the analysis of variance test). (I) Mice were treated by SCD1 inhibitor A939572 or Vehicle i.p. All regimens were administered for twice a week. Body weight was measured weekly during the treatment. There was no obvious decrease in body weight when administration of A939572. *, P <0.05; **, P <0.01; ***, P <0.001; ****, P <0.0001; NS, no significance, respectively.